ʻO ka pono o nā lāʻau lapaʻau
Hoʻokumu ʻia ʻo COVID-19 e ka maʻi me ka moʻolelo SARS-CoV-2 pathogen, e komo a komo i nā cell host ma o kāna protein spike.I kēia manawa, ʻoi aku ma mua o 138.3 miliona mau hihia i hoʻopaʻa ʻia ma ka honua, me ka nui o ka make ma kahi o ʻekolu miliona.
ʻOiai ua ʻae ʻia nā lāʻau lapaʻau no ka hoʻohana ʻana i ka pilikia, ua nīnau ʻia ko lākou pono e kūʻē i kekahi o nā ʻano hou.Eia kekahi, ʻoi aku ka lōʻihi o ka uhi ʻana o ka lāʻau lapaʻau ma ka liʻiliʻi o 70% o ka heluna kanaka ma nā ʻāina āpau o ka honua, me ka noʻonoʻo ʻana i ka wikiwiki o ka hoʻopaʻa ʻana i kēia manawa, ka hemahema o ka hana kano, a me nā pilikia logistical.
Pono ka honua i nā lāʻau lapaʻau kūpono a palekana, no laila, e hoʻopili i nā maʻi koʻikoʻi i hoʻokumu ʻia e kēia maʻi.Ke nānā nei ka loiloi o kēia manawa i ka hana pilikino a me ka synergistic o curcumin a me nā nanostructures e kū'ē i ka maʻi.

ʻO ka pono o nā lāʻau lapaʻau
Hoʻokumu ʻia ʻo COVID-19 e ka maʻi me ka moʻolelo SARS-CoV-2 pathogen, e komo a komo i nā cell host ma o kāna protein spike.I kēia manawa, ʻoi aku ma mua o 138.3 miliona mau hihia i hoʻopaʻa ʻia ma ka honua, me ka nui o ka make ma kahi o ʻekolu miliona.
ʻOiai ua ʻae ʻia nā lāʻau lapaʻau no ka hoʻohana ʻana i ka pilikia, ua nīnau ʻia ko lākou pono e kūʻē i kekahi o nā ʻano hou.Eia kekahi, ʻoi aku ka lōʻihi o ka uhi ʻana o ka lāʻau lapaʻau ma ka liʻiliʻi o 70% o ka heluna kanaka ma nā ʻāina āpau o ka honua, me ka noʻonoʻo ʻana i ka wikiwiki o ka hoʻopaʻa ʻana i kēia manawa, ka hemahema o ka hana kano, a me nā pilikia logistical.
Pono ka honua i nā lāʻau lapaʻau kūpono a palekana, no laila, e hoʻopili i nā maʻi koʻikoʻi i hoʻokumu ʻia e kēia maʻi.Ke nānā nei ka loiloi o kēia manawa i ka hana pilikino a me ka synergistic o curcumin a me nā nanostructures e kū'ē i ka maʻi.

Curcumin
ʻO Curcumin kahi hui polyphenolic i hoʻokaʻawale ʻia mai ka rhizome o ka mea kanu turmeric, Curcuma longa.Hoʻokumu ia i ka curcuminoid nui i loko o kēia mea kanu, ma ka 77% o ka huina, ʻoiai ʻo ka curcumin II hui liʻiliʻi he 17%, a ʻo curcumin III ka 3%.
Ua ʻike ʻia a ua aʻo ʻia ʻo Curcumin, ma ke ʻano he mole kūlohelohe me nā waiwai lāʻau.Ua kākau maikaʻi ʻia kona ʻae a me ka palekana, me ka nui o ka nui o 12 g / lā.
Ua wehewehe ʻia kona hoʻohana ʻana he anti-inflammatory, anticancer, a antioxidant, a me ka antiviral.Ua manaʻo ʻia ʻo Curcumin ma ke ʻano he mole me ka hiki ke ho'ōla i ka edema pulmonary a me nā kaʻina hana ʻino ʻē aʻe e alakaʻi ai i ka fibrosis māmā ma hope o COVID-19.

Kāohi ʻo Curcumin i nā enzyme viral
Manaʻo ʻia kēia ma muli o kona hiki ke kāohi i ka maʻi iā ia iho, a me ka hoʻololi ʻana i nā ala inflammatory.Hoʻoponopono ia i ka transcription viral a me ka hoʻoponopono ʻana, hoʻopaʻa me ka mana kiʻekiʻe i ka enzyme protease nui viral (Mpro) he kī nui i ka hana hou ʻana a kāohi i ka hoʻopili viral a komo i loko o ka cell host.Hiki ke hoʻopau i nā hale viral.
ʻO ka maʻi maʻi hepatitis C, ka maʻi maʻi immunodeficiency kanaka (HIV), ka maʻi Epstein-Barr a me ka maʻi influenza A.Ua hōʻike ʻia e kāohi i ka 3C-like protease (3CLpro) ʻoi aku ka maikaʻi ma mua o nā huahana kūlohelohe ʻē aʻe, me ka quercetin, a i ʻole nā ​​​​lāʻau lapaʻau e like me chloroquine a me hydroxychloroquine.
Hiki i kēia ke ʻae i ka hōʻemi ʻana o nā ukana viral i loko o ke keʻena kanaka i ʻoi aku ka wikiwiki ma mua o nā lāʻau lapaʻau liʻiliʻi ʻē aʻe, a pēlā e pale ai i ka piʻi ʻana o ka maʻi i ka maʻi ʻeha hanu acute (ARDS).
Kāohi ia i ka papain-like protease (PLpro) me kahi 50% inhibitory concentration (IC50) o 5.7 µM i ʻoi aku ma mua o ka quercetin a me nā huahana kūlohelohe ʻē aʻe.

Kāohi ʻo Curcumin i ka mea hoʻokipa cell host
Hoʻopili ka maʻi maʻi i ka mea hoʻokipa hoʻokipa hoʻokipa kanaka, ka angiotensin-converting enzyme 2 (ACE2).Ua hōʻike ʻia nā haʻawina hoʻohālike i ka curcumin i ke kaʻe ʻana i kēia launa pū ʻana o ka virus-receptor ma nā ala ʻelua, ma ke kāohi ʻana i ka protein spike a me ka ACE2 receptor.
Eia naʻe, he haʻahaʻa ka bioavailability o ka curcumin, no ka mea, ʻaʻole ia e hoʻoheheʻe maikaʻi ʻia i ka wai a paʻa ʻole i ka media wai, ʻoi aku ka nui o ka pH kiʻekiʻe.Ke hāʻawi waha ʻia, hoʻomaka ka metabolism wikiwiki e ka ʻōpū a me ke ake.Hiki ke hoʻopau ʻia kēia pilikia me ka hoʻohana ʻana i nā nanosystems.
Hiki ke hoʻohana ʻia nā mea lawe nanostructured he nui no kēia kumu, e like me nanoemulsions, microemulsions, nanogels, micelles, nanoparticles a me liposomes.Ke pale nei ia mau mea lawe i ka haʻihaʻi metabolic o ka curcumin, hoʻonui i kona solubility a kōkua iā ia e neʻe i loko o nā membrane biological.
ʻEkolu a ʻoi aku paha nā huahana curcumin i hoʻokumu ʻia i ka nanostructure i loaʻa i ke kūʻai aku, akā liʻiliʻi nā haʻawina i nānā i ko lākou pono e kū'ē iā COVID-19 i vivo.Ua hōʻike kēia mau mea i ka hiki o nā mea hana ke hoʻololi i nā pane kūlohelohe a hoʻemi i nā hōʻailona o ka maʻi, a wikiwiki paha i ka hoʻōla.